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Pilot project: "Identification of glycolipid receptors of virulence factors from zoonotic agents".
The initial step of numerous prokaryotic and viral infections consists in the binding of adhesins of pathogens and toxins secreted by bacteria to the cell surface of susceptible target cells of the host, whereupon the actual disease is triggered. All animal and human cells have glycolipids in their plasma membranes, which are used as docking structures by a variety of bacteria and viruses. After...